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USMLE USMLE Exam Syllabus Topics:

Topic	Details
Topic 1	Cranial and peripheral nerve disorders Cellular basis of the immune response and immunologic mediators
Topic 2	Deficiency primarily of humoral immunity Immunologic and inflammatory disorders
Topic 3	Biology of tissue response to disease Disorders of balance and spatial orientation
Topic 4	Infectious and inflammatory disorders of the eye Adverse effects of drugs on the immune system
Topic 5	Eating disorders and impulse control disorders Pharmacodynamic and pharmacokinetic processes
Topic 6	Adaptive behavioral responses to stress and illness Biochemistry and molecular biology
Topic 7	Maladaptive behavioral responses to stress and illness Immunologic and inflammatory disorders
Topic 8	Adverse effects of drugs on the hematologic and lymphoreticular systems Disorders associated with immunodeficiency

Reference: http://www.usmle.org/step-1/#question-formats

USMLE Step 3 is open to candidates who already hold their USMLE Step 1 and Step 2 certificates. Step 3 is a two-day exam that assesses whether candidates are able apply medical knowledge and understanding of biomedical and clinical science essential to unsupervised medical practice. This is the final USMLE exam which leads to the license to practice medicine without supervision - the ultimate goal of medical students and professionals willing to practice medicine in the United States. Step 3 represents the final assessment of physicians assuming independent responsibility for delivering general medical care.

USMLE Step 2 is a one-day (8 hours) exam. Similar to the Step 1, the test items are divided into blocks, and test item formats vary within each block, with the total number of exam questions equaling to 355.

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USMLE Step 1 is a one-day (8 hours) examination. It includes 322 multiple-choice questions divided into 7 blocks of 46 items (60 minutes are given for completion of each block).